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The thicker-walled ventricles pump blood outof the heart. Albert and J.E.Knoefel (eds), Clinical Neurology of Aging, 2nd edn. It has been also reported that CaMKII is upregulatedin heart failure and correlates with reduced ejection fraction.In end-stage failing myocardium, both in animals and humans,CaMKII inhibition reduces sarcoplasmic reticular calcium leakand enhances myocardial contractile function. No additional benefit was gained in 3600 mg/day over 1800 mg/day

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